A New Inherited Abnormality of Human Hemoglobin

A new inherited abnormality of hemoglobin and its interaction with sickle cell hemoglobin.

V. NEEL, M.D., PH.D. T HIS REPORT deals with a new inherited abnormality of hemoglobin encountered in American Negroes. The existence of this traitcame to light ill the course of extensive clinical and genetic studies u’egarding the sickling pheuiomenon. Among the individuals examined thei’e were anumber of patients ‘it-h a hemolytic syndrome associated with erythrocytic sickling in whom neithe...

Hemoglobin I: an inherited hemoglobin anomaly.

By D. L. RUCKNAGEL, E. B. PAGE AND W. N. JENSEN S TUDIES OF HEMOGLOBIN by the various technics of electrophoresis aud alkali denaturatiomi have resulted imi a strikimig development in the knowledge of abnormal hemoglobins amid in the hereditary hemolytic amieniias, some of them never previously recognized. During the course of the examination of the electrophoretic properties of the hemoglobimi...

Hemoglobin I: An Inherited Hemoglobin Anomaly

By D. L. RUCKNAGEL, E. B. PAGE AND W. N. JENSEN S TUDIES OF HEMOGLOBIN by the various technics of electrophoresis aud alkali denaturatiomi have resulted imi a strikimig development in the knowledge of abnormal hemoglobins amid in the hereditary hemolytic amieniias, some of them never previously recognized. During the course of the examination of the electrophoretic properties of the hemoglobimi...

Characterization of a chemical abnormality in hemoglobin G.

The development of methods (3,4) for localizing the differences in the primary structure of the human hemoglobins has prompted a study of the differences between the structures of hemoglobins A, S, and G. Knowledge of the structural differences might give new insight into the genetic control of the structure of these hemoglobins (5, 6). The results of this study, which are presented here, indic...

A New Variant of Human Fetal Hemoglobin: Hb Froma.